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KMID : 0377619680140050423
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Korean Jungang Medical Journal
1968 Volume.14 No. 5 p.423 ~ p.428
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The Leukocyte Ascorbic Acid Content of Some Koreans
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Kim, Han-Seob/金漢燮
Bang, Seok Woon/Cheon, Hyong Won/Chung, Tai Young/Lee, Ki Yung/房錫運/全鎣元/鄭泰英/李基寧
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Abstract
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It has been suggested that the ascorbic acid content of the leukocytes of whole blood is a more reliable index of vitamin C nutrition of body tissue than the level in blood plasma. 1-4) The plasma value. of this vitamin fluctuates widely depending upon the ascorbic acid intake just prior to the measurement; a scorbutic patient who ingests a large amount of vitamin C in the morning on the day of plasma ascorbic acid measurement would show high value despite of vitamin C starvation at the tissue level. This may be the main reason why there are so many modifications of "tolerance test" or "loading test" with plasma or urine sample in use to detect ascorbic acid deficiency for nutritional survey or clinical purpose.
In conducting a serial studies on leukocyte biochemistry, we have preliminarily determined the leukocyte ascorbic acid content in 20 hospitalized patients to find the values remarkably well within the ranges reported by others in foreign literatures; and will present the data of these with the addition of those obtained from blood donors. We believe that the significance of such determination gives not only a direct means of evaluating nutritional status of vitamin C but also serves as a tool for many other experimental works that would affect the bodily vitamin C content in animal.
Corresponding plasma ascorbic acid level of those studied for leukocyte content will also be presented in the following.
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